The Use of the developing egg in virus research

London His Majesty's Stationery Office 1936 4to. Original printed wrappers of publication. Heading: Privy Council/Medical Research Council. Special Report Series No. 220.Some paper breaks alond spine which has printed title. Collation: 1-58, xii (publications of Privy Council). Very Good Pamphlet (Item ID: 0000552)


"Sir Frank MacFarlane Burnet was a virologist and immunologist from Australia who took his medical degree from the University of Melbourne. In November 1931 Burnet was invited by Sir Henry Dale to spend two years at the National Institute for Medical Research at Hampstead, London, working on animal viruses. Here he made his first attempts to grow virus on the chorioallantoic membrane of the chick embryo, on which many viruses produce a small white pock or clone of infected cells. It was a technique in which he was soon the acknowledged expert. He used it to estimate the number of infecting particles in the starting material, and as such it was an important means of quantification. Burnet was not the first to notice that chick embryos inoculated with virus did not produce any antibodies, but he made the connection between this and reports of blood-group chimaeras in twin cattle, and an earlier report that if mice were infected with virus before birth they did not react to it. He suggested that a state of immunological tolerance could be induced in animals if they were exposed to an antigen before birth, when a foreign antigen might be accepted as self. He failed to demonstrate it using either virus or red cells, but in 1956 Peter Medawar and his group in London managed to induce tolerance using nucleated cells that persisted in the animal body. Medawar and Burnet were to share a Nobel prize for this work in 1960."(ODNB)

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